u/manmadeofdex

▲ 1 r/Drugs

Does this sound like withdrawal?

So I got a liter of 1,4 BDO a few days ago, and dosed it as follows (note I think it was lower potency/contaminated as I was vomiting a lot and for a while after, and didn’t feel much on 3ml which I was told was a pretty high dose

Thursday

3ml 10:45 AM

1ml 12:07 PM

4ml 12:30 PM

2ml 1:15 PM

5ml 5:30 PM

Friday

8ml 2:08 AM

9ml 9:00-9:30 am
(now here’s where I fucked up)

After this dose I went out for a walk for a smoke, and it kicked in hard on the way back. I was knocking into everything, and just about when I got to my front door I got nauseous and couldn’t find my keys so I ended up on the stoop puking my guts out. Some asshole called an ambulance on me even tho I said I was fine, and I couldn’t convince them not to take me to the ER. In the ER they said I was agitated and gave me 0.5mg iv lorazepam at like 12:45 prolly which I feel like would have been what pushed me over the edge.

Around 8pm I got a few small shakes and vomited a few times, but neither of those symptoms really went for more than a few hours. Then last night I could not sleep at all until like 11:30am when I had a dream about getting covered in bugs in a fancy restaurant. I was also getting CEVs comparable to a low dose of benadryl while I was trying to sleep. Am I in withdrawal? I definitely don’t feel awful and it seems like a possibility but it was also not that long use

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u/manmadeofdex — 10 hours ago
▲ 2 r/Drugs

1,4-BDO/GHB thoughts

Just got 1l of ts from china took 3ml feeling hella good, any combinations worth doing with this? Thinking this could be hella good either with MDMA, Shrooms/shroomalogs, and nitrous or with meth. Idk tho

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u/manmadeofdex — 2 days ago
▲ 65 r/Drugs

TOP 5 coolest BRAIN RECEPTORS IN MY OPINION

  1. NMDA receptor
    Shit’s so neat the effects it’s blockage has, and shit like excitotoxicity that means normal activity is actually somewhat bad? Neat as hell

  2. GHB receptor
    Niche receptor activated by a few GABAergic sedatives that’s stimulating, plus the fact GHB is not only produced endogenously, but also has its own receptor!?? Insane

  3. Sigma-1 Receptor
    Now this one’s so cool cause we don’t really know how it works or what it does, but a bunch of different drugs activate it as a minor action, and I have the theory it’s responsible for autonomous entities cause both DMT and DXM hit it

  4. GABA A receptor
    Now this one’s an absolute goat for all around effects, 90% of downers target it and it’s where all those classic sedative effects come from. My interest in it comes from the niche hallucinogenic action it exhibits with certain PAMs like Zolpidem and agonists like Muscimol. Some of my coolest and most bizarre trips have been on ambien, and it’s so neat how the main inhibitory receptor has such a niche and strange hallucinogenic effect to it, especially with how different it is from any other hallucinogenic class

  5. Kappa Opioid Receptor
    Reverse MOR that causes dysphoria and bizzare hallucinations is such a neat premise for a receptor. The existence of painkillers made to be more selective for KOR to discourage abuse is like something out of a cyberpunk movie, but our own bodies allow for that! And that’s not even getting in to the mindfuck that is Salvia

Honorable mentions:

Serotonin 5-HT2A receptor
It’s a bit too normal and well understood to make the list, but you gotta admit how cool the psychedelic experience is

M1 Muscarinic Acetylcholine receptor
This one’s not super interesting in its effects when hit or blocked, but I thank God every day mine is working normally and flowing free

Cannabinoid CB1 and CB2 receptors
Weed’s neat, it can be whatever you need it to be. The receptors it works on affect so many different systems and have such interesting effect, especially with full agonists

Mu Opioid Receptor
Idk I love opioids it’s sick we have a receptor just for them so we don’t have to suffer

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u/manmadeofdex — 3 days ago
▲ 83 r/Drugs

“Meth is really a psychedelic when you think about it” - Hamilton Morris

What do you all think about this quote by our beloved journalist? It’s an unconventional way of looking at meth, but with its affinity for the serotonin transporter I can’t help but think there’s something to it!

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u/manmadeofdex — 8 days ago
▲ 56 r/meth

This drug gets too much hate

Everyone I know loves drugs, they drink, they smoke, they do blow and ket and pop addies and trip and all, which is great and I do that too, but when I tell them I boof meth *I’M* the weird one? *I’M* the junkie? Fuck you. This is just as powerful an entheogen as its 3,4-Methylenedioxy analog! I feel like God has decided to take me, and make me a king for a day. I could do anything. I am not a very adventurous man though, so I just relax and listen to music. I am enjoying the luxuries of my royalty. I think of Aldous Huxley’s description of Downwards Self-Transcendence in The Devils of Loudun, and how it can be swung upward to observe God

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u/manmadeofdex — 8 days ago
▲ 42 r/Drugs

Theory: 5-Methoxy-3,4-Methylenedioxymethamphetamine would be the greatest drug ever

Think about it for a minute. Phenethylamine is the base of all stimulants and many psychedelics, but it’s pretty mid and unremarkable. But when you add a methyl chain to the alpha position, it becomes the prototypical, much loved functional stimulant Amphetamine. Then you take that amphetamine, so good for focus but not so fun, and add a second Methyl chain to a nitrogen atom, and you get the recreational king Methamphetamine! So much more fun, euphoric, relaxing, than its monomethyl predecessor, but it does not stop here. What happens if you want that beautiful euphoria of Meth to give spiritual and enactogenic, even psychedelic experiences? Add a METHYLene bridge and two oxygen atoms to the third and fourth positions, and you get MDMA, possibly the greatest drug of all time for its sheer versatility, from parties and recreation to some of the most powerful therapeutic effects for treating conditions like PTSD. MDMA is the best we have now, extremely beautiful experience that takes its toll on your body and mind if you try to abuse it. But I think we can do better. There is one Methyl-related chain we have yet to affix to the chemical, and every one before has greatly increased its power. I propose we affix a Methoxy chain to the 5th position of MDMA, to create the ultimate methyl phenethylamine, 5-MeO-MDMA. This drug has been created, but I do not know of its use. I suspect it will be beyond our wildest dreams.

The chain goes

Level 0: Phenethylamine
|
V
Level 1: Amphetamine
|
V
Level 2: Methamphetamine
|
V
Level 3: MDMA
|
V
Level 4: 5-MeO-MDMA

I do not know if further levels exist. I wrote this on level 2

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u/manmadeofdex — 8 days ago
▲ 20 r/Drugs

Meth is such an interesting high

It feels nothing at all like you’d think from the archetype of the tweaker. I don’t feel racy, I’m relaxed. I feel social, almost like mini-MDMA (it’s got that little serotonin magic like MDMA, DXM, or psychedelics, but applied to a stimulant instead of an enactogen, dissociative, or psych). Im really just chilling, not tweaking even having boofed it. I feel smart as ever, but less restrained in my thinking, and more open to enjoyment and having fun. I’m not saying that tweakers don’t exist or even that it can’t feel racy, I’ve only eaten and boofed it, and never binged or redosed, as I’ve only had it through fake adderall (which I knew was meth when I took it), which I know makes a big difference, but in the immediate high I feel myself loving it, but not for the reasons I’d expect one to fall in love with meth.

I don’t like most stims, although I have an extensive history with both Amphetamine and Methylphenidate, so I expected something similar to that but more intense. Racy, nauseous, but absolutely locked the fuck in on whatever you’re doing. I don’t really enjoy that feeling, but I need to use it sometimes (I do genuinely have ADHD, although I can mostly function without stims, they can be very useful.) It’s not like that at all. Again, it feels much more like MDMA for me. Yes I’m stimulated, but that’s not where the euphoria comes from. It’s much more the social feeling, and the relaxation of it. Where it is stimulating, it’s like a strong cigarette after a long break, times a hundred. I can feel it coursing through my veins even like an hour or two in. My legs are trembling. I feel cool, both in temperature and demeanor. It’s more an autism treatment than an adhd one, I’m social like I’m on MDMA but without the enactogenic effects. If I were to abuse it, it would be fore this social feeling. I’m really relaxed too, full on couchlock just been sitting in my beanbag talking to people on my phone

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u/manmadeofdex — 8 days ago
▲ 2 r/meth

Stim music recs needed (testing addy the responsible way:boofing that shit)

We feeling hella good bought an “addy” off the plu cause he was out of mdma, decided to test that shit by shooting it straight up the boofhole and God bless him, the plu was lying this shit ain’t speed. I feel like a million bucks, not much of a stim guy but this shits special, like a half step towards MDMA from adderall with the serotonin, hell I feel relaxed on it, not racy. I’m listening to Viagra Boys- Street Worms rn but I don’t know too much good stim music, like I said I’m usually a downers and psychs guy besides mostly non-recreational use of ADHD meds (although lowkey after doing meth for the first time other stims hit much better and are more recreational). Punk, Metal, Indie Rock, or rock in general are my usual favorites but I’ll check out anything.

Also before someone says some shit about “crystal/ straight meth would be cheaper” yeah ik but plu’s got what he’s got and ik if I got it cheaper or in bulk I’d have a massive problem immediately, that’s how all my drug problems start (got a liter of GHB (bdo technicall) coming next week, pray for me). Will try crystal when I get the chance tho

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u/manmadeofdex — 8 days ago
▲ 4 r/Drugs

Testing adderall the responsible way:

Dissolving and shooting that motherfucker deep up my boofhole and seeing if I feel fantastic (meth) or just locked in (amphetamine). Feel like a million bucks so it seems like the guy was lying, god bless him. Listening to viagra boys - Street Worms rn if anyone has any stim music recs lmk them (particularly punk, metal, indie rock, or really any kind of rock but I’m open to whatever). I’m not much of a stim guy usually only really use them as functional aids for ADHD (prescribed Adderall, Concerta, and Ritalin) (also not counting enactogens cause MDMA is my favorite drug besides DXM but it feels more like a stimulating psychedelic than a psychedelic stimulant when I’ve done it, idk if that makes sense), but I’ve done meth a few times now through the form of fake addys (ik ik I can get it cheaper if I get crystal but the plugs got what he’s got and cheap/bulk access is the way I end up with a problem with most things (1l of 1,4BDO coming next week, pray for me)), & it’s recreational in a way I’ve never found another stimulant. It’s so clean, I don’t get jittery at all and if anything I feel sedated and relaxed like MDMA, presumably cause of the serotogenic nature of meth compared to amphetamine. Shits so fun. But I usually do downers so idrk any stim music

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u/manmadeofdex — 8 days ago