What are all the well known ones, like Candy flip, etc.
What combos are out there that deserve a title?
Feel free to use your creativity and have fun with naming certain drug combos and let's see which ones get the most up votes. I'm curious too see where this goes !
6 of us decided to do acid and some of us took 100 Ug, 200 Ug, but me and my buddy took 400ug cause we're more experienced. But the crazy thing is his wasn't kicking in until we all finally started to come down.
Has this ever happened to anybody? I felt bad for him cause we thought his were duds, but lo and behold when our other friends started getting ready to go home, he started finally hallucinating!
I had ketamine and another 400 Ug and decided to just drop some more and we had a blast. He's not on any medications or anything and is 160 lbs and in his 20's. We all ate pizza before dropping the blotter about an hour after we ate.
I took the Psyduck then the Golduck, he took the Meowth
I've never cried over something so beautiful before in my entire life. The autumn colours made this landscape look like another planet entirely.
I believe the term is called becoming "Awestruck"
The following is from the Imperial College London extended-state DMT (“DMTx”) pilot study, published by Lisa Luan and colleagues.
This is the study where 11 experienced psychedelic users were given intravenous DMT continuously for about 30 minutes, rather than the usual few-minute DMT peak.
Source: Psychological and physiological effects of extended DMT
"In a single-blind, placebo-controlled study using a within-subjects repeated measures design, 11 healthy volunteers received up to four different doses of bolus plus slow-rate infusions of DMT over 30 min. Dosing sessions were separated by at least 2 weeks. On dosing visits, EEG activity as well as subjective and autonomic effects were measured acutely and retrospectively, and blood samples were collected for pharmacokinetic purposes (EEG findings and pharmacokinetic modelling will be published elsewhere).
The study was approved by the National Research Ethics Service Committee London – Brent and the Health Research Authority and was conducted in accordance with the revised Declaration of Helsinki (2013), the International Committee on Harmonization Guidelines in Good Clinical Practice, and the National Health Service Research Governance Framework. The study was sponsored and approved by Imperial College London’s Joint Research and Compliance Office and the National Institute for Health Research/Wellcome Trust Imperial Clinical Research Facility gave site-specific approval for the study. The study was conducted under a Home Office licence for research with Schedule 1 drugs."
The study involved:
11 healthy volunteers
7 men and 4 women
Mean age 37.09 ± 8.93
Each participant could receive up to four different DMT doses
Sessions were separated by at least two weeks
DMT was administered as an initial IV bolus followed by a continuous infusion
The active DMT administration lasted approximately 30 minutes
EEG, ECG, subjective effects and blood DMT concentrations were measured.
Normally, IV or inhaled DMT produces an extremely rapid rise and fall. The researchers wanted to solve the biggest problem with studying DMT:
By the time someone can tell you what happened, much of the experience is already over.
The DMTx approach was essentially to enter the DMT state rapidly and then hold the person there.
The researchers used a bolus + continuous infusion:
A relatively large IV dose was given initially.
A pump then continuously administered smaller amounts for approximately 29–30 minutes.
The infusion rate was calculated from pharmacokinetic models to compensate for DMT being rapidly metabolized.
The goal was to keep brain/plasma DMT levels—and therefore subjective intensity—relatively stable.
Eleven healthy volunteers participated: 7 men and 4 women, with a mean age of about 37 years. They were experienced with psychedelics, including DMT, which was important because the researchers didn’t want inexperienced participants suddenly trapped in a prolonged breakthrough state.
They tested four dosing regimens, with initial boluses ranging approximately from 6–18 mg, followed by infusion rates of roughly 0.63–1.88 mg/min. The sessions were separated rather than repeatedly performed back-to-back.
Carl was particularly significant because he was the first person to undergo the DMTx procedure and was the only participant reported to have completed all five of his extended sessions at breakthrough levels.
He described the experience as initially involving movement and instability, almost as though he had to become accustomed to navigating the state.
One of the things he described was seeing what he interpreted as alternate lives.
He also described an experience resembling a profound 5-MeO-DMT-like state, followed by what he characterized as an alien invasion.
But the interesting part was his interpretation of what happened next: rather than simply encountering one “alien,” he described multiple entities or tribes of entities, and an underlying sense of plurality within unity.
Carl also described something particularly unusual across repeated sessions: a sense that there was continuity between different DMT experiences.
In other words, the experience didn’t necessarily feel like:
“I went somewhere completely new each time.”
Instead, some aspects seemed to him more like:
“I’ve been here before.”
This is one reason the extended-state concept is so intriguing to experienced DMT users.
Carl appears to be the most extensively documented participant.
He was the first person to undergo the extended DMT protocol and is described as the first person to complete all five DMTx doses during the pilot phase.
He has subsequently discussed his experiences in numerous interviews, including a 2025 Hamilton Morris interview and a 2026 Danny Jones interview.
What he has described
Carl has talked about:
•Initially being overwhelmed by the speed of the transition
•Learning to navigate the DMT environment rather than simply being swept through it
•Encountering apparently autonomous entities
experiences involving groups/tribes of entities rather than a single being
•Being taken beyond what he described as the familiar “white room”
•Encountering different forms of “oneness”
•Experiences involving multiplicity within unity
•A profound sense that human life is extremely brief and valuable
•Entities seeming to have an entirely different conception of existence
In the 2023 DMTx panel, Carl described his strongest encounter as involving an alien/foreign presence that seemed to co-opt the space, followed by encounters with tribes of entities rather than one individual entity.
He has also discussed learning to maintain agency during the state—something he considers one of the most important differences between ordinary DMT and the extended state.
His later interviews go considerably further than the 2023 panel, including his interpretation of the experiences in terms of consciousness, technology and what he calls hyperhumanism.
This is probably the participant for whom the most raw material is publicly available.
Alexander is probably the second-best documented participant.
He wrote an extensive first-person account for The Standard.
He reported five DMTx dosing sessions.
And his descriptions are extraordinarily specific.
His experiences
He described entering what felt like a completely separate reality within seconds.
He encountered a planet-sized spider that appeared to entice him closer and then ensnare him.
He described communicating with it and interpreting the encounter as revealing something about his own fear of intimacy.
He subsequently connected that insight to his marriage and said the experience affected how he approached intimacy.
In another session he encountered colourful chinchilla-like entities.
They appeared to communicate using what he described as a visual language that he couldn’t understand.
This is one of the more interesting reports because the communication wasn’t simply conventional speech—it appeared to him as information conveyed visually.
In another session he encountered hat-wearing elf-like entities that appeared to be watching or investigating him from a distance.
The psychological aftermath
Alexander said his experiences brought up a previously avoided personal issue involving a family member.
He eventually had a difficult conversation that he had been avoiding for years.
He described the experience as helping him confront suppressed emotions and ultimately improving his communication with people close to him.
He also reported increased creativity and mental flexibility afterward and connected the experience to the ideas eventually developed in his book The Bigger Picture.
Alexander described putting considerable preparation into the experiment.
He worked with a coach experienced in nonordinary states, stopped drinking alcohol, practiced meditation and breathwork, and developed techniques for remaining calm and observant.
One of his mantras was essentially not to surrender to astonishment—because the first few minutes could be overwhelmingly intense.
His actual DMTx experience was particularly interesting because he described a sense of continuity.
Rather than experiencing a single explosive hallucination, he described:
•Teachings
•Interpersonal lessons
•Metaphysical experiences
•A sense of an ongoing environment
•Geometric environments
•He described repeatedly finding himself in something resembling a geometric cavern, with other imagery occasionally superimposed upon it, including what was described as a playground-like environment.
That is quite different from the idea of DMT being merely random visual noise.
His description was more like entering an environment that had structure and continuity.
Jack is a neuroscientist/pharmacologist and machine-learning researcher, and Noonautics explicitly identifies him as an Imperial DMTx participant.
He was one of the four participants on the major 2023 DMTx panel.
His preparation
Jack said he’d taken more than 100 different psychedelic compounds before the experiment.
He used controlled breathing to manage the intense physical sensations and approached the experience partly through his knowledge of neuropharmacology.
He described encountering an elf-like creature that appeared to be manipulating or rearranging some sort of material or equipment.
Importantly, the creature didn’t seem to be there specifically to interact with him.
It appeared to be doing its own work, while he was essentially observing it.
That distinction fascinated him.
Pastoral/primal environment
He also described a beautiful pastoral environment populated by large orangutan/simian-like beings.
The panel transcript describes them as approximately 10 feet tall, with children, and compares the scene to an Attenborough documentary where the animals know the observer is there.
He interpreted the experience as communicating something about primal being and interconnectedness with nature.
Jack reported seeing Carl in one of his visions.
This became significant because he later told Carl about it. The two discussed whether the apparent connection meant anything or whether it could simply have resulted from their friendship and familiarity with one another.
The researchers were deliberately cautious about participants sharing their experiences because they didn’t want one participant’s descriptions to prime another participant’s experience.
Jack’s experience is particularly interesting because he had a pharmacological/scientific background.
He said he hadn’t done the same degree of ritualistic preparation as some of the others, but had extensive experience with unusual states of consciousness.
He used controlled breathing to manage the physical sensations and relied partly on his understanding of pharmacology to prevent the initial bodily sensations from turning into fear or panic.
One of his most memorable experiences happened at the lowest dose.
He described being suddenly confronted by extremely distinct entities during approximately the first ten minutes.
One was described as an elf-like humanoid, with delicate features and a petite body.
But the really bizarre part was what the entity appeared to be doing:
operating or manipulating some sort of machinery/equipment.
Jack described it as looking almost like an elf working on some kind of machine in front of him.
This is particularly interesting because it wasn’t merely:
“I saw a strange creature.”
The entity appeared to have agency and a task.
That’s one of the recurring features of DMT reports generally: people frequently describe perceived beings as doing things, rather than simply appearing as static hallucinations.
Anton is particularly interesting because his stated interest wasn’t simply “what does DMT look like?”
He was interested in whether apparently autonomous entities could actually communicate with humans.
His DMTx experience:
He described entering a village-like environment populated by humanoid entities.
There appeared to be:
•Adults
•Children
•Groups of beings
•Apparently social organization
He interpreted them as evaluating whether his consciousness had transitioned from an ordinary/material realm into something resembling a realm of light.
The “cord”
Two male entities appeared to examine him and determine whether some kind of connection/cord between him and his ordinary state remained intact.
They then positioned themselves on either side of him, almost like guardians.
The information tablets:
This is one of the stranger reports.
The entities apparently presented him with tablets containing information.
He felt the information was extremely important, but he couldn’t understand or “download” it.
He repeatedly asked what it meant.
The beings essentially just grinned at him.
Important qualification:
Anton himself emphasized that his most powerful extended entity experience wasn’t actually one of the Imperial DMTx sessions.
He described a roughly 90-minute experience after ayahuasca as being more powerful.
That’s important because online accounts sometimes incorrectly attribute all of his stories to the Imperial experiment.
Anton was particularly interested in the question of entity encounters before entering the experiment.
He approached the experience with a considerable amount of preparation and treated it almost as a sacred or ceremonial undertaking.
He described meditation, abstinence from sex/drugs/alcohol and trying to enter the experience with reverence rather than simply treating it as a recreational psychedelic experience.
His most powerful experience discussed publicly wasn’t necessarily one of the DMTx sessions itself; he described a separate extremely extended experience involving ayahuasca.
But his DMTx-related interest centered heavily on the possibility of communion with apparently sentient beings.
He also described an experience involving a village-like environment populated by humanoid entities.
The entities appeared to be evaluating whether his consciousness had transitioned from a material state into what he perceived as a realm of light.
The panelists also discussed things that happened between their DMT sessions.
Several reported unusually strong experiences of what they interpreted as synchronicities.
These included:
•Noticing unusual coincidences
•Suddenly perceiving connections between unrelated events
•Heightened awareness of people and events
experiences they interpreted as telepathic
unusual encounters involving people they believed they recognized
One participant describing what they interpreted as precognition
One participant reportedly described experiencing something like seeing his future mind approximately six months ahead. Another described receiving something resembling a “key” associated with 360-degree perception and multiplicity/unity.
**OCD is actually one of the more interesting emerging areas of psychedelic research**, but the evidence is still much smaller than for depression, PTSD, or substance-use disorders.
**Psilocybin — the strongest psychedelic evidence so far**
The most important study is a **2026 randomized clinical trial by Francisco Moreno and colleagues**. It followed up on Moreno’s original 2006 pilot work.
In the 2026 study:
**15 people with OCD** participated.
They received either **100 µg/kg psilocybin, 300 µg/kg psilocybin, or lorazepam placebo**.
Participants subsequently received repeated psilocybin sessions.
OCD was measured using the **Yale-Brown Obsessive Compulsive Scale (Y-BOCS)**.
After the 8-week treatment period, **73.3% met the study’s definition of treatment response** (≥35% reduction in Y-BOCS).
**40% were in remission**.
Benefits were still present six months later, although they had diminished.
No serious adverse events or psychotic symptoms were reported in this small sample.
The huge caveat is **n=15**. That’s far too small to establish psilocybin as an effective OCD treatment on its own.
2026 randomized psilocybin/OCD study
**The original 2006 study**
Moreno et al. conducted an early **open-label pilot study** in people with OCD. Participants received different doses of psilocybin and researchers observed reductions in OCD symptoms.
Interestingly, symptom improvement wasn’t obviously proportional to the intensity of the psychedelic experience. This was one reason researchers became interested in whether psilocybin might have a direct effect on OCD circuitry rather than simply producing psychological insight.
**There are also ongoing Yale studies**
Yale School of Medicine currently has a study specifically examining **psilocybin for OCD**, including the neural mechanisms that might explain symptom changes.
That research is particularly interesting because scientists aren’t just asking
*“Does psilocybin reduce OCD?”*
They’re trying to determine **what happens in the OCD brain when it does.**
**Ketamine:**
Ketamine isn’t a classic psychedelic, but it has been studied in OCD.
A small randomized study found that **a single IV ketamine infusion could rapidly reduce OCD symptoms**, with effects lasting at least several days and in some participants around a week.
The particularly interesting finding was that people with **constant intrusive thoughts** seemed to respond particularly well.
Ketamine is pharmacologically very different from psilocybin/LSD—it primarily affects the **glutamate/NMDA system**, rather than acting as a classic 5-HT2A psychedelic.
**LSD, DMT, mescaline and others**
There are **much weaker data** for these in OCD.
Researchers have found:
historical LSD case reports
individual reports involving mescaline
retrospective surveys involving LSD, psilocybin, DMT and other psychedelics
animal/preclinical work
observational studies
One 2023 retrospective survey of **174 people** reported that classic psychedelics were associated with reductions in OCD symptoms, with some people reporting effects lasting weeks or months. But because people were reporting their own experiences retrospectively, this **cannot demonstrate that psychedelics actually caused the improvement**.
A recent review of the field similarly concluded that **psilocybin has the most promising signal**, while rigorous controlled trials remain scarce.
**Why researchers think psychedelics might work for OCD**
One interesting hypothesis is that OCD involves excessively rigid/repetitive brain networks.
Psychedelics temporarily alter activity and connectivity in networks involved in:
\-Repetitive thought
\-Self-referential thinking
\-Cognitive rigidity
\-Habit formation
\-Prediction and error processing
The idea isn’t necessarily that psychedelics simply *“erase”* obsessive thoughts. Instead, they may temporarily make these normally rigid networks **more flexible**, potentially creating a window in which psychological/behavioral patterns can be changed.
That’s particularly interesting when combined with **ERP (exposure and response prevention)**, because ERP essentially trains the brain to stop treating intrusive thoughts and anxiety as signals requiring compulsive responses.
**Where the science stands in 2026**
I’d rank the evidence roughly:
**Psilocybin → promising but preliminary**
**Ketamine → promising preliminary evidence**
**LSD → interesting historical/observational evidence**
**DMT/ayahuasca → very preliminary**
**Mescaline → extremely limited**
**Microdosing → insufficient evidence for OCD**
The really significant development is that **we now have a randomized psilocybin OCD trial with surprisingly strong preliminary results**, rather than merely anecdotes. But with only 15 participants, we need substantially larger trials before anyone can confidently say psilocybin is an effective OCD treatment.
If you’re interested, I can also post how **the actual OCD brain mechanisms s**pecifically how psilocybin appears to affect the brain's **cortico-striato-thalamo-cortical (CSTC) circuit, default mode network, serotonin 2A receptors, and compulsive habit loops**.
That’s probably the most fascinating part of the research. But for now, I'd just like to know what you guys think, thanks a ton!
I'm wondering if anybody has tried both and can tell me how their Personal Experiences felt like. I've read up on them enough but I'm wondering about their own experience. I'd like an answer from both male and females who have tried one or both.
Question 1:
Which one is better for sex? I'd like an answer from both female and males.
Question 2:
Has anybody ever combined 6-APB, 2CB, 4-HO-MiPT or 5-MEO-MiPT together?
The reason I'm asking is because 2-cb is apparently a sexual enhancer for females, but not males. The combination of the three is something I'm interested in trying with a girl in the future.
Even if you've only tried 2-CB alone, did you notice any sexual enhancements as a female?
And lastly, if you've tried 2-CB & MiPT together, please share how that experience was as a female.
Be as detailed as you can, if you'd rather PM me instead of commenting how it was just send me an invite.
Thanks a ton!
Video: The race to Commercialize the World Most Powerful Psychedelic | WSJ
I just watched a Wall Street Journal video about the race to commercialize 5-MeO-DMT, and honestly, I found the direction of this pretty fascinating.
The really interesting part is the short duration. And fast antidepressant effects it provides, sort of like Spravato Ketamine's nasal spray, it's comes in one dispenser with two doses of 28mg for each spray, (56 mg total per day)
Unlike psilocybin, where the acute experience can last several hours, pharmaceutical versions of 5-MeO-DMT are being developed with an experience that can be measured in minutes rather than hours.
From a medical perspective, that could be a huge deal.
Imagine a psychedelic treatment that produces a profound alteration of consciousness but doesn’t require a patient to spend an entire day in a clinic. If clinical trials ultimately demonstrate that the antidepressant effects can persist beyond the acute experience, that’s potentially a very different model for psychedelic medicine.
There are currently companies developing pharmaceutical versions, including AtaiBeckley’s BPL-003 and GH Research’s GH001.
And then there’s the part that really caught my attention:
Eli Lilly agreed to acquire AtaiBeckley for roughly $2.8 billion upfront, with the deal potentially reaching $3.8 billion with milestones.
So this isn’t just a bunch of psychedelic enthusiasts talking about the future anymore. Major pharmaceutical money is actually entering the space.
Obviously, none of this means 5-MeO-DMT is proven to be a miracle antidepressant. The drugs still have to demonstrate efficacy, safety, durability and tolerability in larger clinical trials.
But it does make me wonder...
Are we watching the beginning of psychedelics transitioning from an underground/subculture phenomenon into mainstream pharmaceutical medicine?
And if 5-MeO-DMT really can produce therapeutic effects after such a short acute experience, could its intensity ironically become one of its biggest advantages for medical use?
Curious what everyone here thinks.
I took LSD right before I fell asleep so I'd wake up with the sunrise and skip the come up which can be uncomfortable. I opened my eyes and it looked like I was tied up by lights. I had to take a picture and video because these lines were rapidly shifting and moving and when I reviewed the video, it actually was just rapidly moving on its own! I wish I could post the video because it looks incredible sober, but when I first saw it I was astonished by the brightness reflecting off my pale legs 😂
PS. I like to take lsd before bed so I wake up to skip the come up, I live for the comedown on lsd. It's such an amazing part of the experience in my opinion. (Besides the peak effects)
I recently came across something I found fascinating and wanted to hear what this community thinks.
There’s a mushroom from Yunnan, China called Lanmaoa asiatica that has been known locally for generations. When it’s eaten raw or undercooked, people reportedly experience vivid hallucinations of tiny human-like figures (“little people” or xiao ren ren). Or as I like to think, those "underpants gnomes" from that one episode of south park 😅
What makes this especially interesting is that researchers haven’t found the usual hallucinogens. It doesn’t appear to contain psilocybin, muscimol, or other well-known psychoactive compounds, and scientists suspect it may contain an entirely new psychoactive molecule that hasn’t yet been identified.
That got me thinking about something I’ve heard discussed in psychedelic research before: reports of encounters with small humanoid beings, elves, dwarves, or “machine elves” across different substances and cultures. Researchers like David Luke have explored these recurring themes, although there’s currently no evidence that they’re anything more than recurring features of human perception or cognition.
I think it’s interesting that a completely different mushroom-with what may be a completely different chemistry-can reportedly produce such a specific and unusual type of experience.
Do you think this points toward:
Common neural circuitry that different psychoactive compounds can activate?
Universal archetypes of the human mind?
Cultural influence on how people interpret unusual perceptions?
Or something else entirely?
I’d also love to know if anyone here has read the primary research on Lanmaoa asiatica or has thoughts on what kind of compound might eventually be discovered.