u/methylcyclosarin

I was reading this article linking COMT variant to response to amphetamines and noticed from my genetic profile that I have val/val variant associated with low base levels of dopamine that usually benefit more from stimulants.

If you have done a 23andme or any other DNA test download the raw text file. Exctract it. press ctrl F to search and type rs4680, G is val and A is met. It codes for catechol-O-methyltransferase. An enzyme which breaks down cetocholamines such as dopamine and norepenephrine, val/val polymorphism can show up to 3-4x COMT activity than met/met leading to lower baseline dopamine and higher rate of breaking down dopamine.

I'm curious to see the disturbution of the polymorphism in the sub and your stimulant of choice and wether you noticed the supposed inverted U functional response to dopamine signaling. And also wether you notice a shorter duration or a harder crash due to faster catabolism of catechols.

I might have overdone it with speed and ended up sleep deprived and decided to randomly listen to a long youtube video about the history of scotland or something and the narrator hads an outragous accent, I mustve fell asleep and woke up later with videos from the same channel playing.
I went about my day then scrolled on instagram a bit, i was noticing that strangely i am getting a lot of scottish reels, then i see a video from a creator i know and this fucker is straight from the highlands butt cheeks flapping out the kilt and everything. I was going to panic I went to the comments trying to see if it was a bit. It wasn't.
Now everyone except people who enunciate clearly or those with distinctive regional accents just somehow are scottish, hell even I involunterily end up speaking in scots unless i focus on what I say. If I really focus I can hear their accent but the moment they slurr their speech or not enunciate something I end up hearing it in scottish.

please help me.

edit: I'm genuinely serious