u/HabitFromTheLot

Just wanna thank the AKA

Just wanna take a minute and thank the American Kratom Association for showing me my way back to the trap house today. If it wasnt for Mac Haddow Id probably have speant the rest of my life as a functional and employed adult. Imagine how lame that might have been. Thankfully they put a stop to that.

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u/HabitFromTheLot — 3 days ago

CaTs cLaW

So what do yall think will become of brands like Buzzers and stuff next week?

Obviously the reputable 7 providers will stop selling MGM but Im wondering what yall think will happen to the cheaters like Buzzers and stuff? (Please dont get hung up on a specific brand name. im talking about the product category overall)​

Will they pivot to inactive tabs? Keep doing what theyre doing until someone goes to jail? Idgi? They never admitted they were selling MGM but now thats gonna be super illegal...

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u/HabitFromTheLot — 4 days ago

KD has 200mg Speciociliatine Tabs...

Edit : Its so fucking good fam. Read on. I feel so much less hopeless about this ban now that I tried these.

According to what Ive read speciociliatine should be about 3x the potency at the mu receptor as Mitragynine, and its got dual agonism going with kappa.

This, on paper, sounds pretty dank.

But we have some other factors to consider here. One redditor has an in-depth journal about their testing of leaf with high speciociliatine content, and seemed to associate it with sleep. Do we think these are gonna be at all workplace friendly? Obviously we're using opioids, so some relaxation is to be expected, but do you think these will knock someone out?

(Answered through my test. Yes, its significantly heavier than MIT but no, its not so sleepy I couldnt work a night shift on it. IDK if it actually made me sleepy or if it just wasnt stimulating like MIT so I interpreted that as more somnilent)

Is it speciociliatine or speciogynine that is supposed to cause the wobbles? Id assume thats the Kappa receptor right, causing nystagmus? I'm a weirdo and actually like wobbles so thats not a huge detergent for me but Im still curious if I should expect it.

(Answered through test : its speciogynine that causes wobbles. I mega-dosed these speciollatine tabs and didnt get any nystagmus or overstimulation. If id have ate ​the same number of full-spectrum tabs Id have definitely got wobbles. Not so with these. if they cause wobbles it happens at more than 500mg)

Can anyone whos used speciociliatine isolate share how it was euphoria wise? Just because something has 3x the agonism at the receptors doesn't automatically mean it's 3x as euphoric. Look at SR. Its way more agonistic than a lot of opioids but has no euphoria.

(Id say the euphoria was pretty comparable to MIT, but the overall profile felt stronger. If you chase euphoria you might want to try combining these with a little bit of regular MIT. The analogy Im going with is these compare to MIT the way Pseudo compares to 7oh.)​

Last : what else is in the specio*** scaffold? Unlike mitragynine, the language of the ban doesnt automatically cover speciollatine derivatives. We can hypothetically build on this scaffold and stay legal for a while.

Ive seen people talk about how speciogynine can be oxidized and hydrogenated into a pretty extensive little family of alkaloids, and I see where theres a lot of overlap here with the psychedelic opioids, so this could be a whole Pandoras box if you think about it.. Wonder what would happen if I pulled the speciollatine out of these and soaked it in rose Bengal and bubbled it with oxygen??? Anyone know where I can find straight speciollatine from to play with?

(Post-trial edit : This is incredibly promising. I didnt think the next wave would come from within the Kratom plant but now Im eating my words a little. This has mad potential.)

Ive got an order going in for some of them now. Ill let yall know how they go down. But seeing if anyone has some conversation around them in the interim...

I have a pretty good feeling about these though. Sean has the good reputation he has for a reason.

We'll see soon.

(Edit : Order recieved. 3 day shipping window from Idaho to Florida. KD's shipping speed always amazes me. I cant get packs from within my state as fast as these guys get me shit here from Idaho. its like Sean is personally driving my pack to my. mailbox when Im not looking)

Update summary: they get you noticeably better off than Mitragynine. Not quite 7oh levels but wayyy better than MIT. (I have a sort of half-theory that maybe it just doesnt have crosstolerance with mitragynine, but idk I think its just stronger really)

No wobbles, even though I mega-dosed. the high dose probably contributed to my sleepiness, but I slept 12 hours straight on the tale end which is the first good night sleep Ive gotten since 7oh was banned here.

Warmer, heavier, more drowsy, but way more effect. Id compare it to what Pseudo is to 7oh. Its a lot more physically weighty but milligram per milligram its definitely more potent with a higher ceiling.

I genuinely dont understand now why we were ever fucking with mitragynine. if this was an option all along why the actual fuck did I ever waste my time with MIT?

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u/HabitFromTheLot — 14 days ago

Bromantane Interactions? (SR-17018, Kratom, etc...)

Curious if there have been any reported significant interactions here between Bromantane and certain mu-opioid agonists like Kratom, SR-17018, 7Oh, etc?

I depend on opioid replacements, I use Kratom (leaf) fairly regularly, enough to have altered liver enzymes from it, and I do cycles of SR17018 to reduce my tolerance, usually a one week cycle of each, so Kratom one week, sr the next, repeat.

I know that people have experienced fairly serious negative interactions between Kratom and certain stimulants, for example there is a high risk of seizure combining *afinil compounds with Kratom, certain empathogens are ruled out as dangerous, etc, all centered around cP450 liver enzymes (like CYP3A and CYP2D6) and their function metabolizing stimulants...

Would this make Bromantane a no-go for me?

Its not all stims.

Anyone advise here?

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u/HabitFromTheLot — 16 days ago

Catalyst Edge Labs Cats Claw Tabs

Buyer Beware : these contain no active compounds.

Since Floridas ban I have been using about 10grams of commercial kratom leaf in capsule form per day. I peg these as a little weaker in anxiolytic effect than a single capsule of grey-bag leaf. if tonight turns into an anxiety night Im done for.

Vendor marketed these *specifically* at my state so I had high hopes. Florida is on the front line of shit. We sold Ket analogs in our headshops here. usually we get good stuff first and it gets banned here first.

Took two of these and Id say Im sober. My nose is running too.

Anyone else tried these? Is there a dosage sweet spot Ill hit if I keep eating them or are they just... meh?

edit : the vendor got back to me and suggested I take 4-6 tabs... making these significantly less strong than a traditional OPMS leaf capsule. thats how much opms leaf I take at a time, 6 caps. then I top off in groups of 4.

edit 2 : followed vendors advice ate 6. no significant change in body chemistry.

edit 3 : 14 total consumed over 8 hours. no effects to report. these are an inactive tablet..

if catalyst edge labs are going to go down this route they need to step way back and evaluate how these are dosed, priced, and marketed. in their current form they arent worth it at all, and will have people accusing them of being scammers.

I dont doubt they had a thought here, but with their marketing and positioning these alongside existing kratom products they are misleading people into thinking theyre going to get you high, when on the backend theyre pitching them as more like an anxiolytic nootropic rather than a legal high. if their website lined up with their customer supports messaging there wouldn't have ever been an issue.

0/10, stick to Kratom leaf if youre dependent on opioids living in a banned state.

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u/HabitFromTheLot — 17 days ago

How I Tapered (More Cheat-Proof)

Use : 250mgish per day M : I used this protocol first to go from M to 7, and then to get from 7 to MIT, and Im now back down to raw leaf kratom.

I bought a gram of good and a gram of shitty powder. I cut the gram of weaker stuff a further 50% using a MIT extract powder. 

Phase 1, every time I took a dose of my alks, I replaced it in the same jar with the weaker concoction. So Id scoop some into my mouth, and put the same number of scoops of drastically weakened 7 back in the jar. With every dose, I was weakening my supply. 

Then, entering into phase 2, youre gonna do the same thing with pure MIT to this jar of weakened 7oh. Every time you scoop replace it with MIT.

Eventually, one scoop-and-replace at a time, youll have a jar thats essentially just pure MIT. From there, repeat the scoop-and-dilute to the MIT extract with leaf. Eventually you'll just give up one day and stop visiting the jar.

This technique will prevent you from cheating. You cant reverse the damage done to the jar. Every dose is automatically weaker than the last with no way to go back.

reddit.com
u/HabitFromTheLot — 27 days ago

Couldnt this be what everyone is looking for?

Why dont we just ask american shaman or someone similar to make this (alks within the akuammadine scaffold, or herkinorin derivatives)? Idgi? Ive actually been wondering why we arent making this since Florida banned 7oh a year ago. It is the akuamma equivalent. Trace alkaloid typically a metabolyte with a higher but still ceilinged effect profile. Anecdotal evidence of ODs but rumored to have a safety profile as good or better than 7...

https://www.reddit.com/r/Scholar/s/omnhfsr3cQ

Akuamma is actually a super interesting path in general. Akuammine itself is a antagonist so even just akuammadine without the akuammine present is said to be extremely euphoric and recreational compared to the plant.

Then stuff gets real spicy when you start tacking stuff onto the akuammadine molecularly speaking...

"Most notably, the introduction of a phenethyl moiety to the N1 of 2 produces a 70-fold increase in potency and a 7-fold increase in selectivity for the μOR. The in vitro potency of this compound resulted in increased efficacy in the tail-flick and hot-plate assays of antinociception. The improved potency of these derivatives highlights the promise of exploring natural product scaffolds to probe the opioid receptors."

https://pmc.ncbi.nlm.nih.gov/articles/PMC10037270/

The issues? Much like all 7oh has to start as Mitragynine, to flesh this out into a greymarket product would require refinement of an "average joe" tech, like the oxone method was for 7 manufacturers.

Theres also the issue where mitragynine speciosa is more abundantly produced than akuamma. The supply chain is in place to support the whole thing. We were able to piggyback on an already existing kratom industry for raw materials, where as the akuamma industry is quite small, and would need to expand if popularity increased.

Alternatively, theres Herkinorin..

Herkinorin is an experimental, semi-synthetic analog of salvinorin A that acts as a mu-opioid receptor agonist. It is an unapproved research compound and does not have an official medical dosing schedule, nor is it formally listed on the federal DEA Controlled Substances Schedules, though its parent compound salvinorin A is tightly regulated or scheduled at the state level (such as Schedule I in Florida).

&

Unlike most μ-opioid receptor agonists, herkinorin does not promote the recruitment of β-arrestin 2 to the intracellular domain of the μ-opioid receptor, or induce receptor internalization.[6] This means that herkinorin may not produce tolerance and dependence in the same way as other opioids, although some development of tolerance through other mechanisms has been observed,[7] and some other analogues related to herkinorin can recruit β-arrestins.[8]

https://en.wikipedia.org/wiki/Herkinorin

This one's interesting because the synthesis pathways are FAR more fleshed out, if perhaps a bit more complex from a regulatory standpoint.

"The process typically starts with salvinorin A, which is the primary psychoactive component of the Salvia divinorum plant.Structural Modification: The transition from salvinorin A to herkinorin involves chemical reactions that first remove the C2 acetate group to form salvinorin B. Subsequent esterification or benzoylation at that same site introduces the aromatic benzoate group required to create herkinorin."

Still, it is everything we are asking for in a replacement. It could be a fine scaffold to build on. Also, unlike Akuamma, theres a fairly evolved Salvia market in existence already to support raw materials.

u/HabitFromTheLot — 28 days ago