Peyronie’s Disease: 83% plaque reduction on ultrasound but still have hourglass deformity – has anyone gone on to fully recover?
Hi everyone,
I’m a 27-year-old male with Peyronie’s disease and I’ve been under the care of a specialist since November 2023. I’ve had serial ultrasounds and elastography performed by the same clinic, and the results have shown consistent improvement at every follow-up.
Ultrasound results
November 2023 (diagnosis)
Plaque: 13.3 × 8.8 × 2.8 mm
Volume: 0.172 cm³
Elastography index: 2.66
Non-calcified plaque
May 2024
Plaque: 10.5 × 7.2 × 2.8 mm
Volume: 0.111 cm³
35% reduction from previous scan
Elastography index: 2.06
November 2024
Plaque: 7.3 × 5.5 × 2.6 mm
Volume: 0.054 cm³
51% reduction from previous scan
Elastography index: 1.90
July 2025
Plaque: 5.5 × 4.0 × 2.5 mm
Volume: 0.029 cm³
46% reduction from previous scan
Elastography index: 1.36
Overall, the plaque volume has gone from 0.172 cm³ to 0.029 cm³, which is approximately an 83% reduction.
Treatment
I’ve been treated with:
Peyflog
Sclero-Hyal
Alpavita EC
There have been occasional interruptions due to shipping and stock issues, but overall I’ve remained on treatment long-term and my scans have consistently improved.
My situation
Despite the objective improvements on imaging, I still feel like I have:
Residual hourglass deformity
Some perceived loss of size/girth
A penis that doesn’t yet look normal to me
My doctor has gradually extended my follow-up appointments from every 6 months, to 8 months, and now to 12 months, which I assume is a positive sign.
My questions
Has anyone here had scan results showing this level of plaque reduction and then gone on to achieve a normal-looking penis again?
Did your hourglass deformity continue improving after the plaque became very small?
Did anyone regain lost girth or length after the plaque was mostly gone?
Has anyone achieved what they would consider complete or near-complete recovery?
Based on these scan results, would you consider me close to the finish line or is there still a long way to go?
I’d be interested in hearing from anyone with similar ultrasound findings, especially those who had measurable plaque shrinkage over multiple years.
Thank you.