u/MrNeverEverKnew

How long should I be waiting after a day of Kanna until taking 4-Pro-MET (4-HO-MET) (or other serotonergics) again? How many days?

Ich hab reine Muscimol-Gummies (Jellies). Mit wie vielen mg würdet ihr für das erste Mal anfangen?

Ich nehme außerdem täglich 200–300 mg Pregabalin gegen eine Angststörung.

Hat jemand von euch schon mal Muscimol zusammen mit Pregabalin (oder Gabapentin) genommen oder weiß etwas über mögliche bzw. riskante Wechselwirkungen?

Falls die Kombi nicht gefährlich ist: Schwächt Pregabalin die Wirkung von Muscimol stark ab oder hebt sie vielleicht sogar komplett auf?

Mich interessiert Muscimol vor allem wegen der möglichen antidepressiven, angstlösenden, beruhigenden und vielleicht auch etwas “erleuchtenden” Wirkung.

Ich möchte aber natürlich keine gesundheitlichen Risiken eingehen, indem ich es mit Pregabalin kombiniere. Ich könnte Pregabalin zwar theoretisch einen Tag weglassen, habe aber Sorge, dass ich dann Entzugs- oder Rebound-Symptome bzw. stärkere Angst bekomme und mir das die Muscimol-Erfahrung versaut.

Deshalb wollte ich mal fragen, ob jemand Erfahrungen mit der Kombination Muscimol + Pregabalin hat oder etwas dazu weiß.

I have pure muscimol gummies. How much mg would you advise for the first time? I‘m also prescribed Pregabalin 200-300mg a day for anxiety disorder. Ever taken these two together or know more about any possible or maybe risky interactions between these two: muscimol & pregabalin? Or maybe if not risky, would pregabalin dull and completely nullify the effects of the muscimol?

I‘m interested in muscimol for it‘s possible antidepressant, anxiolytic, calming, and enlightening effects.

But don‘t want to risk any health issues by combining it with pregabalin - which I probably could exclude for one day, but maybe some withdrawal/rebound/increased anxiety I could feel from not taking it, that would otherwise ruin the muscimol experience. Hence I‘m asking about if these two, muscimol and pregabalin, are okay to take together.

I am prescribed Pregabalin 200-300mg a day, but I could also get over the day with just 100mg, if this is needed for experiencing a DXM trip.

Anyone here who tried taking both together and didn‘t have any issues? Does both combined come with any risky interactions? Does the Pregabalin dull the DXM to a level one would not notice the DXM, or is it ok or even good together?

What dose to try for first time doing DXM? What to watch out for? Empty stomach? Can it be a heavy headspace and/or bad trip (I have a rescue benzo otherwise) but still want to know. What does it feel like from your perspective? The effects? Is it worth it?

Would be very interested.

So to begin: I’m not taking any antidepressants or serotonergic substances. I only have experience with kratom, kava, kanna, cocaine (only once - half a line, mixed into a sausage sandwich), cannabis (I can’t handle it at all, in 9 out of 10 cases it’s awful, overwhelming, leads to depression, anxiety, rapid heartbeat, breathing difficulties, a bit of negative psychosis, etc.).

I have NEVER taken psychedelics before. Even cannabis, which isn’t a psychedelic, was sometimes, if anything, too psychedelic for me, but I think I’m confusing that more with being psychotic (even if visuals/distortions were rarely there, but could have been placebo from fear/panic).

Accordingly, I’m cautious about 4-Pro-MET and have a slight predisposition to bad trips (which only came from cannabis).

T(+0:00) 11:30 AM (4mg 4-Pro-MET)

Today, on an empty stomach, at around 11:30 (T+0:00), I had 4mg of 4-Pro-MET spread on a sausage sandwich and swallowed it (oral). I know for many that’s a low dose, but after what I’ve read or heard from others (e.g. Simon/OPENMIND, who is actually very experienced with substances, but already has an intense experience/effect at 8mg of 4-Pro-MET, which he sees as his max), you really do become more cautious.

T(+1:00) 12:30 PM (12:30)

In terms of effects, I’m not noticing much that would make me think of a psychedelic experience/effect, but I do notice that I’m somehow making more jokes than usual and my mood might already be brighter than usual. Everything is still at a level that could be passed off as placebo.

--

So here are my questions before I continue this trip report (of course - for the benefit of science & the community):

1. How long does it take for 4-Pro-MET to take effect after ingestion, when is the peak, and how long does the effect last? Note: I took it on an empty stomach and still have an empty stomach at T(+1:00).

2. If another 2mg of 4-Pro-MET were added to the initial 4mg now 1h later in the sausage sandwich, would that even be advisable or is it already too late? To reach a total dose of 6mg.

—

EDIT:

T(+2:00) 1:30 PM (13:30) (6mg 4-Pro-MET)

Took another 2mg (so in total 6mg now). Ate half a sandwich 20 minutes after. Still noticing mood enhancement, so better mood, antidepressant effect, reduced anxiety, funnier/jokier than usual, strangely more motivation and focus for work/projects as well as creative stuff, too, but: NO psychedelic effects at all. Will probably try 10mg next time (with some time in between of course). And then if that doesn't reach that level of experience I am aiming for, I'll go for a 15-20mg dosage (with some time/days/week/s in between the last dosing again of course).

So to begin: I’m not taking any antidepressants or serotonergic substances. I only have experience with kratom, kava, kanna, cocaine (only once - half a line, mixed into a sausage sandwich), cannabis (I can’t handle it at all, in 9 out of 10 cases it’s awful, overwhelming, leads to depression, anxiety, rapid heartbeat, breathing difficulties, a bit of negative psychosis, etc.).

I have NEVER taken psychedelics before. Even cannabis, which isn’t a psychedelic, was sometimes, if anything, too psychedelic for me, but I think I’m confusing that more with being psychotic (even if visuals/distortions were rarely there, but could have been placebo from fear/panic).

Accordingly, I’m cautious about 4-Pro-MET and have a slight predisposition to bad trips (which only came from cannabis).

T(+0:00) 11:30 AM (4mg 4-Pro-MET)

Today, on an empty stomach, at around 11:30 (T+0:00), I had 4mg of 4-Pro-MET spread on a sausage sandwich and swallowed it (oral). I know for many that’s a low dose, but after what I’ve read or heard from others (e.g. Simon/OPENMIND, who is actually very experienced with substances, but already has an intense experience/effect at 8mg of 4-Pro-MET, which he sees as his max), you really do become more cautious.

T(+1:00) 12:30 PM (12:30)

In terms of effects, I’m not noticing much that would make me think of a psychedelic experience/effect, but I do notice that I’m somehow making more jokes than usual and my mood might already be brighter than usual. Everything is still at a level that could be passed off as placebo.

--

So here are my questions before I continue this trip report (of course - for the benefit of science & the community):

1. How long does it take for 4-Pro-MET to take effect after ingestion, when is the peak, and how long does the effect last? Note: I took it on an empty stomach and still have an empty stomach at T(+1:00).

2. If another 2mg of 4-Pro-MET were added to the initial 4mg now 1h later in the sausage sandwich, would that even be advisable or is it already too late? To reach a total dose of 6mg.

—

EDIT:

T(+2:00) 1:30 PM (13:30) (6mg 4-Pro-MET)

Took another 2mg (so in total 6mg now). Ate half a sandwich 20 minutes after. Still noticing mood enhancement, so better mood, antidepressant effect, reduced anxiety, funnier/jokier than usual, strangely more motivation and focus for work/projects as well as creative stuff, too, but: NO psychedelic effects at all. Will probably try 10mg next time (with some time in between of course). And then if that doesn't reach that level of experience I am aiming for, I'll go for a 15-20mg dosage (with some time/days/week/s in between the last dosing again of course).

I’m prescribed pregabalin (100–300 mg/day) and diazepam (5–10 mg/day).

I’m planning to try 4-Pro-MET soon. My assumption is that both of these medications - especially diazepam (Valium/benzos) - would significantly blunt or even completely suppress the effects of 4-Pro-MET.

What’s your opinion? What would you recommend if I wanted to get the best possible experience/effects from 4-Pro-MET?

Since I’ve only been taking diazepam daily for the past ~2 weeks, I think I could probably manage one day without it, while still taking 300 mg pregabalin. Would that be a reasonable option?

What do you think?

Has anyone here had experience with a similar situation or this combination of substances?

BTW: The diazepam was only meant to be temporary. I’ve been taking 10 mg daily for almost two weeks, although it’s actually prescribed as needed. Both the diazepam and pregabalin are prescribed. Starting tomorrow, I’ll be tapering off the diazepam again.

Question in title.

Let me know about your dosages?
Why / what for you take each of these meds?
What dosage? How often? Since when?

Question in title.

Let me know about your dosages?
Why / what for you take each of these meds?
What dosage? How often? Since when?

Bisher liegen bereits so einige Berichte über das Alpravalzafon vor (make Tripberichte great again). Viele sind sehr zufrieden damit, aber was genauere Beschreibungen der Wirkung angeht, ist nur schwer was genaues zu finden, was mich verstehen lassen würde, warum denn so viele Alpravalzaon feiern, bestellen, in kürzester Zeit alles konsumieren, und neu bestellen.

Wo liegt bei dieser Substanz der recreational Faktor, der Spaßfaktor, die recreational Effekte oder das anzustrebende High? Und wie fallen diese aus?

Weil bei vielen liest man, es macht halt verpeilt und müde, fast sedierend. Komplett downing.

Wenns nur müde und verpeilt macht und einen nur in die Couch oder ins Bett ausknockt, wieso konsumiert man es dann (ich meine bis auf vorm Schlafen gehen zum Einschlafen)?

Es muss ja irgendwo auch recreational also Spaß-Effekte und ein angenehmes High haben, das nicht nur Verpeilte Müdigkeit und Wegdösen ins Land der Träume umfasst.

Gibt leider nicht viele Erfahrungsberichte, wo Leute sagen, was genau sie machen, wenn sie auf Alpraval sind. Manche berichten sie schauen dann Netflix (was ich auch bei dem absoluren Downing Effekt noch nachvollziehen kann und im Zusammenhang mit Effekten wie Müdigkeit, Couchlocked, Sedierung Sinn ergibt, weil bei Netflix schauen geht das ja klar). Andere berichten, dass sie dann was zocken (Videospiele). Etwas, was zumindest etwas mehr Wachsamkeit, Aufmerksamkeit/Konzentration, Aktivität, Lust und Motivation/Antrieb benötigt als Netflix schauen oder einfach nur zu Pennen. Macht das Zocken dann mehr Bock? Das würde ja dann doch für einen recreational Effekt sprechen.

Ist man besser gelaunt, besser gestimmt, etwas euphorischer, energischer, fokussierter, entspannter (aber nicht im Sinne von sedierter/müder)? Irgendetwas? Warum nimmt man es sonst, außer man hat wirklich Schlafprobleme und nimmst es, um einschlafen zu können oder während RLS oder eines Entzuges oder einer Panikattacke. Ich checke es von den ganzen Erfahrungsberichten her noch nicht so ganz wo der Reiz, das High und die Recreationality von dem Zeugs ist.

Habs bisher noch nicht selbst ausprobiert. Würde mich aber vorher interessieren, was denn die Effekte nun wirklich sind. Wie man sich darauf fühlt bis auf ne öde Müdigkeit und Verpeiltheit, bis man einfach wegpennt oder (bei höheren Dosen) einfach komplett Blackout geht und sich am Ende eh nicht mal an irgendwas mehr erinnert.

Wo ist der Spaß dieser Substanz?

Wo ist der Nutzen dieser Substanz (bis auf für Schlafprobleme)? Wäre es nützlich für wenn man einen schlechten Tag hat, nicht so gut drauf ist, um die Stimmung zu verbessern; oder wenn man ausgehen will, sich mit Freunden treffen will, auf ein Date geht, dass man mehr Lust darauf hat, was zu unternehmen, sich zu unterhalten, was mit Leuten zu machen - wird man gesprächiger, sozialer, etwas lustiger drauf, offener, selbstbewusster? Hilft es also bei sozialer Angst?

Hat es das Potenzial, einen guten Tag auszumachen und nicht nur komplett verballert sein, um dann einzuschlafen?

Muss es ja doch, sonst würden es nicht so viele nehmen, und auch noch nachbestellen, oder täglich mehrere Male nehmen.

Es muss doch einen recreational oder zumindest irgendwo funktionaleren Effekt haben bis auf Schlafinduktion & Blackout.

Ich weiß, das klingt für die meisten wahrscheinlich ziemlich seltsam, aber ich wollte mal fragen, ob jemand ähnliche Erfahrungen hat.

Ich kann definitiv besser lernen, mich besser konzentrieren und allgemein produktiver arbeiten, wenn ich eine kleine Menge Diazepam nehme (meist 5 mg, manchmal 10 mg). Ich habe keine Toleranz, nehme es nicht regelmäßig und eigentlich nur sehr selten. Es wurde mir vor Jahren bei Bedarf gegen Angststörungen verschrieben. Ich habe das Rezept immer wieder erneuern lassen, damit ich es im Notfall zuhause habe, benutze es aber kaum.

Interessanterweise gibt mir eine kleine Dosis Diazepam mehr Fokus, Motivation, Energie, Aufmerksamkeit und Antrieb. Es fällt mir leichter, mit Aufgaben anzufangen, für Prüfungen zu lernen, organisatorische Dinge zu erledigen oder konzentriert am Computer zu arbeiten, Papierzeugs oder organisatorisches abzuarbeiten.

Meine Vermutung ist, dass das Diazepam meine innere Anspannung und Unruhe so weit reduziert, dass ich mich endlich auf eine Sache fokussieren kann. Eigentlich müsste es pharmakologisch gesehen eher das Gegenteil bewirken: Müdigkeit, Konzentrationsprobleme, Benommenheit, Sedierung usw. Bei mir scheint es aber genau andersherum zu sein.

Hat jemand eine Idee, woran das liegen könnte?

Hat jemand ähnliche Erfahrungen gemacht?

Nutzt oder nutzte jemand Benzodiazepine sogar gezielt zum Lernen, für Antrieb/Motivation/Energie oder für kognitiv anspruchsvolle Arbeit?

I know it sounds very strange for the most people but I just wanted to know if someone else had the same experience. I can definitely study better and focus better on studies or that kind of work like paper work, organizational stuff, computer & office work, when I dose a little diazepam (like 5mg, sometimes 10mg). I have no tolerance, I don‘t take them daily, only very rarely. Have a script for it, prescribed for my anxiety as needed, and never touched it for years, still always got the script‘s delivery just to have it in my home, for any case.

Somehow a little diazepam gives me focus, energy, more attention, more will, joy, more drive to start working on stuff, to study, to prepare for exams or get important work done. Where nothing else helps, a little diazepam probably gets my inner anxiety to a enough reduced level of anxiety and inner disorder that I can finally focus, study and get work done. While it pharmacologically seen would normally produce the opposite effects by being a GABAergic downer, like increased sleepiness, reduced focus/attention, brain fog, sedation, or whatever. But no, for me it does the opposite. Why? Anyone any ideas? Anyone same experiences? Anyone also using it during or for studying or work which needs cognitive power, energy, focus and concentration?

—

Little backstory (no must read for the purpose of this thread and the question/discussion, only if you‘re interested - and happy to hear any opinions, suggestions, tips, recommendations or similar backstories of you re this):

It might be a special individual thing, me suffering from (treatment-resistant) depression, social anxiety & ADD. Symptoms occured since I was born. First not noticed - obviously, because when you’re a child, you don’t have that level of consciousness and reflection to feel that dysfunction or disorder or illness and the connected symptoms. Later I connected my behavior of when I was a child, of that what I remember, and that what my family told me about how I was and acted as a child, with the symptoms and diagnoses I have nowadays, since I was 15. The whole time since I was born, I can find all these symptoms in my old mini me. It is like I was born with that illness, the depression, the anxiety, the mental and cognitive „disorder“. Some speak of biological depression while most say that’s not a thing. From what I learned about me, the connections of my old me as a child, every memory I have, everything what my parents or family members told me about me being a child, it definitely seems like I definitely was born with this disease. And also from the genetics as the types and behaviors of some of my ancestors, it doesn’t seem to be too unrealistic. I mean obviously, why shouldn‘t it be possible or real or a thing that a human would be born with diseases like depression or anxiety, social anxiety or AD(H)D when there also are humans who are just born with parkinson, CFS, or other neurological problems and illnesses. It‘s all neurological in the end, neurochemical, biochemical, biological, in the end physiological, as that is what our brains and by that also our psyches and mental states are, physiological, well, whatever you want to call it. Same as some are born paralysed, numbed, unable to walk, speak or see. It‘s all physiological. But when someone says, I was born with depression, 99% say: NO, that‘s NOT possible. It‘s all coming from outer experiences and circumstances that come with time from experiencing and reacting to it (which can be biologically determined from birth).

Anyhow:
I first consciously noticed the symptoms and saw something is wrong and felt the mental pain and all the restrictions when I was maybe 14-15 years old. With 15 it was so severe, I secretly called a therapist & psychiatrist without telling anyone. Started visiting them regularly. Tried 15+ meds, 4 different therapies (2 depth-psychological/biographic/analytical talk therapies, 2 cognitive behavioral therapies/CBT), hypnosis, dozens of different supplements and nootropics, exercise, switched docs many times. Only thing working was gym (but it was by far not doing enough, even when I hit the gym daily for a year + gym takes so much effort and drive and strength which as we know is not given a lot or all time or not at all when suffering from depression, especially when it‘s psychosomatic, or because the depression leads you to physiological destruction and regression/degeneration of your body by disregarding your physical needs, your body‘s needs, your health - hence not able to go to gym, mentally AND physically). Got prescribed Pregabalin. That helped. But that‘s something one or at least I can not take daily, 1. because of dependence, 2. because of tolerance (it just doesn‘t give me the relief of my symptoms when taken daily, but does when taken only sporadically as needed) but the thing is the disease I have is a daily thing, a every second thing from the moment I open my eyes when I wake up to the moment I close them at night before sleep. Every single second this disease dominates my psyche and my body, continously without break. It‘s all I feel mentally, all I feel physically, and all I think about because it (the depression, the anxiety, the social anxiety, the cognitive dysunction, and all its connected symptoms that come with it like lack of drive, anhedonia, negative thought spirals, lack of appetite, weakness in body, angst, bad mood, no energy, and so on), obviously just dominates and vehemently restricts every little aspect of my life. There‘s no second or moment or situation or aspect of my life where any of these symptoms or the restrictions that come with it would not touch them or have some impact on them. Only things I still haven‘t tried but all the docs I had never were open to prescribe me or get me access to are: irreversible MAOIs as Nardil (Phenelzine) or Parnate (Tranylcypromine) - I already had Moclobemide which is a reversible MAOI though and is one of the 15+ meds I tried that all failed/had no success or reduction of my symptoms). Then there is rTMS and Ketamine therapy. No doc was open to get me to one of these neither. Even if they know about my long story of medical trials of all different medication classes and groups and therapies and so on, and that they all failed. Still a NO from all. That would be too „over level“ , one too much. They would not recommend that… well, yeah, okay, i guess, youre the doc

I know it sounds very strange for the most people but I just wanted to know if someone else had the same experience. I can definitely study better and focus better on studies or that kind of work like paper work, organizational stuff, computer & office work, when I dose a little diazepam (like 5mg, sometimes 10mg). I have no tolerance, I don‘t take them daily, only very rarely. Have a script for it, prescribed for my anxiety as needed, and never touched it for years, still always got the script‘s delivery just to have it in my home, for any case.

Somehow a little diazepam gives me focus, energy, more attention, more will, joy, more drive to start working on stuff, to study, to prepare for exams or get important work done. Where nothing else helps, a little diazepam probably gets my inner anxiety to a enough reduced level of anxiety and inner disorder that I can finally focus, study and get work done. While it pharmacologically seen would normally produce the opposite effects by being a GABAergic downer, like increased sleepiness, reduced focus/attention, brain fog, sedation, or whatever. But no, for me it does the opposite. Why? Anyone any ideas? Anyone same experiences? Anyone also using it during or for studying or work which needs cognitive power, energy, focus and concentration?

—

Little backstory (no must read for the purpose of this thread and the question/discussion, only if you‘re interested - and happy to hear any opinions, suggestions, tips, recommendations or similar backstories of you re this):

It might be a special individual thing, me suffering from (treatment-resistant) depression, social anxiety & ADD. Symptoms occured since I was born. First not noticed - obviously, because when you’re a child, you don’t have that level of consciousness and reflection to feel that dysfunction or disorder or illness and the connected symptoms. Later I connected my behavior of when I was a child, of that what I remember, and that what my family told me about how I was and acted as a child, with the symptoms and diagnoses I have nowadays, since I was 15. The whole time since I was born, I can find all these symptoms in my old mini me. It is like I was born with that illness, the depression, the anxiety, the mental and cognitive „disorder“. Some speak of biological depression while most say that’s not a thing. From what I learned about me, the connections of my old me as a child, every memory I have, everything what my parents or family members told me about me being a child, it definitely seems like I definitely was born with this disease. And also from the genetics as the types and behaviors of some of my ancestors, it doesn’t seem to be too unrealistic. I mean obviously, why shouldn‘t it be possible or real or a thing that a human would be born with diseases like depression or anxiety, social anxiety or AD(H)D when there also are humans who are just born with parkinson, CFS, or other neurological problems and illnesses. It‘s all neurological in the end, neurochemical, biochemical, biological, in the end physiological, as that is what our brains and by that also our psyches and mental states are, physiological, well, whatever you want to call it. Same as some are born paralysed, numbed, unable to walk, speak or see. It‘s all physiological. But when someone says, I was born with depression, 99% say: NO, that‘s NOT possible. It‘s all coming from outer experiences and circumstances that come with time from experiencing and reacting to it (which can be biologically determined from birth).

Anyhow:
I first consciously noticed the symptoms and saw something is wrong and felt the mental pain and all the restrictions when I was maybe 14-15 years old. With 15 it was so severe, I secretly called a therapist & psychiatrist without telling anyone. Started visiting them regularly. Tried 15+ meds, 4 different therapies (2 depth-psychological/biographic/analytical talk therapies, 2 cognitive behavioral therapies/CBT), hypnosis, dozens of different supplements and nootropics, exercise, switched docs many times. Only thing working was gym (but it was by far not doing enough, even when I hit the gym daily for a year + gym takes so much effort and drive and strength which as we know is not given a lot or all time or not at all when suffering from depression, especially when it‘s psychosomatic, or because the depression leads you to physiological destruction and regression/degeneration of your body by disregarding your physical needs, your body‘s needs, your health - hence not able to go to gym, mentally AND physically). Got prescribed Pregabalin. That helped. But that‘s something one or at least I can not take daily, 1. because of dependence, 2. because of tolerance (it just doesn‘t give me the relief of my symptoms when taken daily, but does when taken only sporadically as needed) but the thing is the disease I have is a daily thing, a every second thing from the moment I open my eyes when I wake up to the moment I close them at night before sleep. Every single second this disease dominates my psyche and my body, continously without break. It‘s all I feel mentally, all I feel physically, and all I think about because it (the depression, the anxiety, the social anxiety, the cognitive dysunction, and all its connected symptoms that come with it like lack of drive, anhedonia, negative thought spirals, lack of appetite, weakness in body, angst, bad mood, no energy, and so on), obviously just dominates and vehemently restricts every little aspect of my life. There‘s no second or moment or situation or aspect of my life where any of these symptoms or the restrictions that come with it would not touch them or have some impact on them. Only things I still haven‘t tried but all the docs I had never were open to prescribe me or get me access to are: irreversible MAOIs as Nardil (Phenelzine) or Parnate (Tranylcypromine) - I already had Moclobemide which is a reversible MAOI though and is one of the 15+ meds I tried that all failed/had no success or reduction of my symptoms). Then there is rTMS and Ketamine therapy. No doc was open to get me to one of these neither. Even if they know about my long story of medical trials of all different medication classes and groups and therapies and so on, and that they all failed. Still a NO from all. That would be too „over level“ , one too much. They would not recommend that… well, yeah, okay, i guess, youre the doc

I’ve had muscimol products sitting around for ages (the gummies, the shot, powder, etc.) but I’ve never actually worked up the courage to try them.
I’m really curious about what the experience is actually like, what it’s useful for, and whether it has any practical or recreational value depending on the dose.

If you’ve tried muscimol before, I’d love to hear about your experience:

What dose did you take?

How long did the effects last?

What was the onset and peak like?

What effects did you notice?

What did you like or dislike about it?

What is it actually good for?

Does it have any recreational value? Is it enjoyable?

Could it be useful or functional for anything in particular?

Please include your dosage and whether you used it once, occasionally, or regularly (daily, weekly, etc.), since that probably makes a huge difference.

Since muscimol is GABAergic, it seems pretty clear - both theoretically and from many reports - that it should promote sleep and often lead to vivid or unusual dreams. For people specifically looking for a sleep aid, that alone could be interesting.

What I’m especially curious about, though, is whether its GABAergic effects translate into meaningful anxiolytic effects. Has anyone found it helpful for anxiety disorders, stressful situations, social anxiety, public speaking, or similar situations?

Does it make you more relaxed, sociable, talkative, or open?

How does it affect mood? Any euphoria? Any noticeable recreational effects?

I imagine a lot of this is highly dose-dependent, especially considering the difference between pure muscimol products and Amanita muscaria itself, which also contains ibotenic acid. From what I understand, ibotenic acid has a much more excitatory profile, whereas muscimol is more inhibitory due to its action on GABA receptors.

Looking forward to hearing some detailed experiences.

Is this (orange) the normal color of dpDMC (crystal form)? Or is this somehow sus? I never saw or tried dpDMC before so would be very grateful for any help with this. Also any info about dosing and what the effects feel like very welcome. ROA should be best via oral, I heard?

Most people would tend to research 3-FPO nasally, obviously because of its similarity with those famous and popular non-RC stimulants. I, until now, only did oral research with it and am asking myself, am I maybe missing something out by not researching via other ROAs (route of administrations) as nasal, sublingual, etc.

Would be interested to hear about your way to go with 3-FPO. Also not only the ROA, but also at what dosage and how often and what effects you experience from it.

Thanks, hugs to y‘all!

I’ve ordered 3-FPO several times now from two different research institutes. From my preferred one, it was always a pure white powder the last three times. Suddenly, with the most recent research material, it arrived as a brownish-yellow powder. Is this normal? And what could be the reason for this?

I’ve ordered 3-FPO several times now from two different research institutes. From my preferred one, it was always a pure white powder the last three times. Suddenly, with the most recent research material, it arrived as a brownish-yellow powder. Is this normal? And what could be the reason for this?

4-Pro-MET mit Pregabalin & Kratom?

Nehme täglich 100-200mg Pregabalin (verschrieben) ein und leider auch 10-15g Kratom. Ich wollte bald 4-Pro-MET ausprobieren und frage mich, ob es irgendwelche Probleme wie gefährliche Wechselwirkungen oder Risiken in der Kombination geben könnte (also 4-Pro-MET + Pregabalin + Kratom)? Das Kratom könnte ich im Falle auch weglassen, wobei natürlich ungern, da Entzugssymptome direkt kommen würden, was 1. generell kacke ist und 2. sicherlich meine Erfahrung auf 4-Pro-MET deutlich verschlechtern würde.

Was meint ihr? Wer Erfahrung mit dieser oder ähnlicher Kombination? Wer Ahnung zu der Pharmakologie/Biochemie/Neurochemie dahinter?