r/Opioid_RCs

All of us in here somehow benefit from the gray drug market. While i wont list their names, you all know what im talking about. From managing cravings to cancer pains, these molecules are neutral tools that when used responsibly can genuinely improve the quality of life for so many people. The war on drugs in the US is doing an absurdly disproportionate damage relative to the benefit; serving as a sorry excuse for improving the health of the public to appear moral and an indispensable tool for controlling the population and incarcerating groups of minorities that are politically inconvenient, while indirectly leading to there deaths, as dealers everywhere make the transition from safer, more well studied opioids to ultra potent ones (not that these are evil, just not the use case for pressed pills) with no regard to the dosing, leading to hotspots in pressies and families burying their loved ones. This market allows the end users to know what they're consuming and properly dose which leads to drastically safer use. But this market isnt invincible, should the media decide to one day run a story on how "dangerous gray market substances" are harming the public, politicians will take advantage and will nuke the market how they did with 7 and peptides. Im aware of MGM15 and thankfully this is a more suitable replacement for the use case, but some molecules, which i wont mention here, are completely irreplicable. From having unique mechanisms of action or preferable side effect profiles, if they schedule it then we're back at square one. The market is better off when less people know about it. Prices will be reduced. Sentences for the providers in forgein countries, which aren't as free as ours, will be less strict leading to better product for the consumer as resources needed wont be as expensive.

Stop telling people where to get their stuff. Stop mentioning RCs in non RC subs. Stop mentioning names of vendors. People cannot be trusted to keep the secret. The less people know, the better. Hopefully one day the legislation changes. But until then, Please stay quiet. This is more than feeling good for some people. For most of us its survival.

DuchessVonD hasnt been active anywhere for a long time and i wanted to ask her about isomethadone because i cant find any info on it so im wondering if anyone has trried it.

I only tried o-dsmt and im cuite curious about this one. Ive seen its nothing like it and more for substitute etc. But I want to try it, I usuallly dose 70 mg o-dsmt every 1/2/3 weeks but all the reports I see are from people with high or very high tolerance. What would be a good/safe dose to start as an opioid naive?

I have the tolerance of an elephant for Proto orally, I won’t give a number because in case someone comes across it they will definitely die. I am on my last scraps. I am going through all my chems that were ordered as Proto and ended up being something else. Protozepyne pretty good. Not as great as regular Proto but last much longer. Isozepyne pretty much garbage orally, keeps WD’s away but does very little for my pain.

I finally got a test result back for something ordered as Proto but came back as Cyclophorine. I had take maybe 1mg orally as an allergy test towards the end of the effectiveness of my normal Proto dose which is extremely higher than that. I nodded the fuck out in my garage and woke up on the floor. I didn’t need to be narcan or anything but I have never fell out like that on anything, is cyclo really exponentially more potent than proto orally?

I would like to hear from people with experience taking both of them orally and a potency comparison between the two,

Thanks

does anyone in here use more than one class of drugs? im aware obviously everyone here is using opioids, but ive decided to return to GHB for a multitude of reasons.. Im seeking advice as to how to regulate my consumption, and avoiding the often lethal GHB + opioid combination i will definitely be tempted to use.. Im aware most people who use opioids are also using benzos, which while only similar in limited capacities mechanistically they share the dangerous multiplication of respiratory depression. How do you guys avoid the temptation of combining them? thank you for any insight.

also, ill be more active in this sub instead of lurking.. hopefully you guys find me interesting, gonna be posting mostly overviews of novel opioids i find interesting pharmacologically!

Hello yall, i just got my hands on some SPB, R-4837, NDI and Cychlorphine, i have a built up tolerance from 5 years of usage of regular opioids, i just did 300ug of Cyc oral 1h ago and it feels fucking amazing.

I wanted to know your experiences with the other substance and how potent are they compared to cyc? If 300ug got me nearly nodding, not at all, i think maybe 800ug could knock me out.

Thanks for the help in advance guys :DD

been out of the scene sense ndi.. anyrhint cool going around atm

I take a couple of d8s and oxy 10s a day, is the k100 morphine pill considered dangerous for my tolerance ?

Tolerance, it is the bane of chronic pain sufferers and recreational users alike.

We all know opioids cause tolerance, and that tolerance leads to higher dosages and those higher dosages lead to harder opioids in a nearly endless cycle that typically results in:

• lack of desired effects antinociception, euphoria, both
• chasing the dragon for decades
• endless cycles of tolerance breaks and withdrawals
• overdose

But what if it didn't have to be this way? What if there were opioids that didn't result in crazy tolerance increases?

I have made multiple edits to this post with nre information from commenters and I added some Reddit links as well. It seems like a decade ago some people were using DAMGO and possibly DADLE to get high, but there is no mention of how it affected tolerance.

#DAMGO Enters the Chat#

DAMGO is the reference standard by which other drugs are measured for μ-agonism. It also shows promise in reducing opioid tolerance in rats. From Wikipedia DAMGOentry:

> DAMGO is a synthetic opioid peptide with high μ-opioid receptor specificity. It was synthesized as a biologically stable analog of δ-opioid receptor-preferring endogenous opioids, leu- and met-enkephalin. Structures of DAMGO bound to the μ opioid receptor reveal a very similar binding pose to morphinans.
> DAMGO has been used in experimental settings for the possibility of alleviating or reducing opiate tolerance for patients under the treatment of an opioid. Such treatment on rats, adding DAMGO to morphine administration, showed that after seven days morphine had as much of an effect at the same dosage as the first day when administered together with DAMGO to the rats, whereas a separate control group of rats that were administered the same dosage of morphine over the course of the same week, but without DAMGO, displayed an increased tolerance and lessened analgesic efficacy toward the end of that week.

There are even a couple references to DAMGO on Reddit that suggest it would work as mentioned above. Unfortunately every single person I have seen reference DAMGO has a long-silent account as of 2026. ^(are they all enjoying opioid-induced pain-free bliss or are they dead?)

EDIT 3 - A user named u/captainfentanyl who was supposedly an English researcher and heavy opioid user that hasnt been active since 2018 made three great comments which you can read in his profile because it seems the post he commented in was deleted and thus the share links to comments wont work. Just look at the profile of u/captainfentanyl and his nearly last comments are about DAMGO. I learned the following:

1. He claims to have used DAMGO a lot
2. It is an easily synthesized peptide
3. IV use is a waste because little reaches the brain
4. It is best "encapsulated" in higher doses
5. It sounds to me like that encapsulation was what we often refer to in 2026 as liposomal encapsulation
6. DAMGO recycles the receptors exactly like the natural enkaphalins
7. If he could, u/captainfentanyl would have a catheter implanted and use DAMGO all day
8. It mimics the body's natural enkaphalins so it is undetectable in drug testing
9. DADLE is also a solid choice for getting high off these opiod peptides
10. All opiod peptides end in the same protein sequence
11. He preferred the pure mu agonism of DAMGO and DADLE to the very large number of fentnyls and opiates he used for recreation
12. He was a connoisseur of opiods and he seems legit to this layperson

What I didn't learn is:

1. Dosages (mg? Picograms?)
2. How to "easily" synthesize DAMGO
3. How to encapsulated it properly
4. How the captain learned all this
5. How the captain acquired his DAMGO (I guess he paid huge prices for research grade chems or he synthesized it himself somehow, he alludes to both I suppose)

DAMGO is mentioned in this 2022 r/DrugNerds discussion titled upgregulation of mu and deltaopiod receptor and it is the only active reference I can find of a human with the handle u/soufside_groovin who claimed to have used it. That user is long silent on Reddit.

> soufside_groovin - 4y ago - "The only thing that I have found that reduces established tolerance is DAMGO peptide, which became suspiciously hard to find recently"

In this 2020 r/Opioid_RCs post damgo / dago peptide u/c_e_n_t_u_r_i appears to be responding to a Reddit account that claimed to use DAMGO, but the moderators of r/Opioid_RCs removed the comment and the account was deleted so there is no way anyone but the MODS of this sub can see what that comment contained.

Mods if you see this please look at the removed comment and see if there is ANY information about human use of DAMGO that could be shared with the community from the comment that linked comment below is responding to here: https://www.reddit.com/r/Opioid_RCs/comments/juvuw5/comment/gcjugt5/

> c_e_n_t_u_r_i •6y ago - "What is the dosing like? That is what I can't seem to find. If it's only a few milligrams or less might be worth it to buy through one of the bio science providers or have my Chinese contact custom synth 100gs for a few hundred."

In this 2017 discussion of endomorphin DAMGO is mentioned and two things I find of note are that someone believes there was a human study (which I cannot find)

> HeroinPillsLovecraft •9y ago - "No, but there's an interesting synthetic peptite DAMGO, which is a mu agonist, itself, but has been used in studies of co-administration with morphine, and then shows no tolerance increase to the morphine over a significant period of time. The human study I read was a year."

and u/TDubbs123456 claims that up the nose is the only way to use it:

> TDubbs123456 •9y ago - "i heard intranasally is the only ROA for these but your saying they don't last long? i can't even find dosage info"

Other discussions on Reddit (I have seen none on BlueLight or elsewhere) seem to center on how easy or difficult it might be to store and use DAMGO. https://www.reddit.com/r/biology/comments/1ts8qi/peptide_damgo_storage_and_use_conditions_advice/

EDIT2 - While scientific chem companies that sell to official laboratories for scientific research say -20C is necessary for DAMGO, it appears that -4C, or 25F, may be sufficient for reconstituted DAMGO. Any old refrigerator can achieve this temperature NP.

#DAMGO PROBLEMS#

1. Only available from actual lab grade chemical companies which to my knowledge require a legitimate business license to purchase chemical samples from
2. Very expensive (hundreds per milligram)
3. Storage (transport also?) requirements needing subzero freezers. (EDIT - This is disputed by users in the link directly above)
4. No Human data outside of 2 internet references of human use with no real details given regarding dosing, storage, etc

#DAMGO ADVANTAGES#

1. Potentially dosed at picogram levels
2. Full bore tolerance destruction
3. Cheap if #1 is true
4. G-protein and not b-arrestin activation would in theory make at least some part of human use "safer"
5. Unlike proglumide which also reverses tolerance, there is no secondary tolerance to deal with

#Why Is There So Little Information#

I understand why Big Pharma hasn't, but I am shocked no one from r/DrugNerds or r/researchchemicals ir even r/RC_Opiods hasn't had some DAMGO whipped up and posted real world information.

Here is DAMGO in all its glory:

H-Tyr-D-Ala-Gly-N-MePhe-Gly-ol.

As someone 6 years ago alluded to, from a technical and financial standpoint, this probably wouldnt be difficult or expensive for a Chinese lab to make would it?

That is my understanding and I am really surprised more people aren't pouring time and money into figuring out how DAMGO does or does not work.

Purely academically speaking, I would fund a clinic's study to save the world's chronic pain sufferers from opiod addiction, tolerance, and suffering if I knew how and thus I assume SOMEONE out there has tried this stuff!

Please don't gatekeep people, please share what you know about DAMGO / DAGO.

I have a trip to Germany coming up in a couple months and I need to get off 7. I honestly don't know what I'm using daily I'm working on establishing that baseline but I'm pretty sure I can get by on under 100 mg as it is now. I've been using it for about 3 months.

I know tapering seven isn't exactly desirable because of its pharmacology but I'm hoping someone here has experienced tapering down. I'm wondering what dose you were able to get down to before jumping off.

I'm not interested in trying SR and Suboxone from the doctor is the last resort. I've detoxed before it extremely high doses of kratom itself so I know what I'm in for. I've got clonidine on hand and if everything goes well with my doctor's visit I'll have gabapentin as well.

Thanks for reading

I take 7 daily. How long do I need to wait til I can take and feel?

I have a question for all of the Cychlorphine users here I’m not sourcing i just want to know has anyone seen a brown batch this is supposed to be the recent batch i seen someone on here speaking on a brown batch but can’t remember who it you are familiar please share how it was. I’m told this brown batch is suppose to be the best yet ham the previous off whiteish, yellow, pink etc etc THANKS!

edit this post was reworded to better explain what I'm asking, I'll leave the original iteration at the bottom. For someone who takes 7-oh for pain, I'm wondering what's a good starting dose for SR-17018. I've heard it can be taken for chronic pain, and I'm looking to order some alongside my next order of 7-oh. I'm hoping to take it to help keep my tolerance on 7-oh low, because it's the only real pain reliever I've found that actually works for my chronic pain.

EDIT#2 to those asking, I take 30-40 mgs of 7-oh regularly, but if things are bad, they can range between 50-75 mgs, and 100mgs in the most EXTREME of situations. My replies/comments have to be reviewed by admin, because I'm new. Which this doesn't bother me overall, beyond the fact that people are being kept in the dark.

II want to thank the people pointing out the confusion my initial post was causing, I greatly appreciate it. I initially wrote this at midnight, during a manic bipolar episode, and it was after I was already awake for 24 hrs prior. That is not a valid excuse though, I should have waited to write this.

Is there anywhere I can see what starting dosage of SR-17018 compared to the starting dosages of 7-OH? I want to buy a couple alongside my next order of 7-oh powder, but I want to know what I'm getting into before I just blindly try it.