r/ketamine

Image 1 — Antidepressant and Psychedelic Drug Interaction Chart
Image 2 — Antidepressant and Psychedelic Drug Interaction Chart
Image 3 — Antidepressant and Psychedelic Drug Interaction Chart

Antidepressant and Psychedelic Drug Interaction Chart

Hello r/ketamine! I'm sharing this Antidepressant and Psychedelic Drug Interaction Chart with the permission of its author, Benjamin Malcolm, Spirit Pharmacist. I want to thank Ben for generously allowing us to host it here. The chart is a part of a comprehensive guide he provides for free on his website:

Spirit Pharmacist - Antidepressant and Psychedelic Drug Interaction and Taper Planning Guide

I've read the guide myself and found it to be very informative and well-written. I'd encourage anyone who takes an antidepressant medication read it before taking ketamine, MDMA, or any psychedelic drug.

Dr. Malcolm is trained as a clinical psychiatric pharmacist and worked in academia for almost five years before dedicating himself to Spirit Pharmacist. He also provides psychopharmacology consulting, courses in psychedelic pharmacy, and a Member Resource and Support Program.

https://www.spiritpharmacist.com/

Note: I had previously shared this a couple of days ago before I knew who had created it, but took it down once I identified the author so I could ask his permission first.

u/AluminumOrangutan — 4 hours ago

How hard would it be to bring k on an international flight?

How hard would it be to get a personal amount of ketamine (~an eighth) on a plane from the Netherlands to the US? Is it worth the risk?

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u/drywalleater05 — 17 hours ago

I love walking on ket

That’s it. I’m on my first days doing it and every night I take it and take large walks on it on my room. I just like the feeling of my body being drunk and my mind being stoned af. I know it can be dangerous somehow but for me it’s really enjoyable and funny.

Btw I don’t have a clue of what dosage i’m in, I’m just doing bumps and stopping when I feel it. Maybe the doses I’m doing are low and that’s why I don’t have the necessity to be in my bed when taking it.

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u/Pablito___ — 18 hours ago

Ketamine at a concert with LSD and mdma

Hi i am an experienced user of psychedelics and similar drugs like nitrous and MDMA. i have tried ketamine once before late night from a friend i met at a festival and loved it. i have my own little bag i am saving for sts9 at the caverns this year and was wondering if you guys think its smart to wait until after the show to try the K? i just have seen people on ketamine be completely still or have to lay down during shows and that doesn’t look like fun. just don’t know how much stronger it will make it with the other substances. thank you let me know if you have any advice

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u/Burglecutt25 — 1 day ago

psychosis or bad experience?

Last night I got high and was fully convinced I was living in the past present and future at the same time. I was hallucinating demons from my bedsheets and staring at me. At one point I held my headphones and could hear the music through my hands and the birds chirping outside my window began to chirp the same rhythm. Idk if what I experienced was psychosis because it was only a few hours and I fell asleep but if anyone wants to add their two cents that would be helpful

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u/jmunderwater — 1 day ago

First time doing k dosage

Hey guys imma get some k soon and wanted to know how much I should take, I have plenty expirence with psyedlics like 450 ug acid and 7g shrooms did some 4th plat dxm and some little bit dmt once, I want to expirence the whole spectrum of k my first time and wanna have a 1 in a live time experience I weigh about 95kg Male

Thanks in advance and maybe you get a trip report:)

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u/Mulabaum — 2 days ago

Stop while you’re ahead

I’m 23. I tried K for my first time when I was introduced to music festivals (Lost Lands 2025) and loved it. It turned from a “one time thing” quickly to an “every single night thing”. I’ve lost the entirety of 2026 to ketamine. Every day was just a meaningless push to make it to night so I could sniff a bunch of fucking K, and now the end of the year is around the corner

Please, if you’re reading this, and in a similar boat as me, just fucking stop. My dick fucking hurts, I have crazy cramps, I’m pissing every hour, and my entire year has revolved around getting out of the public eye as quick as possible so I can rail some lines. I truly believe Ketamine has done wonders for my mental health, but now I’ve gotten out of control with it and completely lost all meaning of why I’m doing it. This is a wonderful drug that has so much potential to be used correctly, but not by doing this degenerate ass shit.

I’ve been drinking & smoking almost every single night for almost 10 years now, since I was like 13, but not even a year of doing K has fucked me up in ways that shit never could. I don’t advocate regular drug/alcohol use regardless, but please just stick to normal shit like some beers and weed if you truly can’t stay sober like myself. KETAMINE IS NOT SUPPOSED TO BE A CASUAL DAILY THING. I thought a lot of the “horror stories” on this sub were bullshit but I can 100% see them happening to me if I keep this up.

Before I know it, I’m gonna be pissing bloody jelly out of my dick into my bed at night because I can’t even keep my fucking sphincter shut. Stop while you’re ahead. Do anything fucking else. Take care of yourself and preserve your future. Because I don’t want this for myself or anyone else

Sorry if I’m rambling, but I just can’t express enough how bad of a habit this is for you. I hope I’ve figured it out early enough, and I hope anyone struggling will take something from this post

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u/Kitchen-Albatross-61 — 4 days ago

Realistically how addictive is K

I have gotten addicted to every substance I’ve tried. Since a kid I always loved feeling ok or quiet. Does ketamine do that? I can’t get hooked on something new but I really wanna try K. I’ve tried getting it countless times and it’s felt like maybe God doesn’t want me to to prevent me from addiction. I already have underlying bladder issues that get worse with any downer I take. I abused psychedelics and kinda fried my brain, don’t mess with them anymore since I got diagnosed with ocd and bipolar and realized how much worse the psychedelics were making my symptoms. Now I just hit the puffco and maybe do some noz every once in a while I don’t want another addiction and I know how complulsive nitrous makes me which is a dissociative. And how perfect everything feels. I just want to try something new and I know ketamine can be similar to psychedelics in a sense. I really miss them and I would love to order some psych RCs or drop a few tabs but I have already seen that pattern play out and it sent me into mania and trying to get on a bunch of meds that never worked lol. Let me know what you guys think I’m sure you’re gonna say don’t do it. Can I do ketamine tonight and not feel the need to do it tomorrow? Or next week? Does your body physically need it like other drugs or is it just a mental craving not actually caused by the chemical but by you?

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u/Silver_Commission_61 — 3 days ago

Has anyone tried microdosing K for anxiety and OCD?

There is a legal site that has been brought to my attention in the USA that operates in a Hims/Hers Telehealth style and it will allow me, in the state of Florida, to legally obtain Ketamine which I can microdose for my anxiety. Has anyone here tried legally microdosing Ketamine for anxiety and OCD?

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u/nelsne — 4 days ago

Does K Make you Assess your Drug Use?

Wondering if anyone else has this experience. Twice when I’ve used ketamine, my thoughts spiral into analysis of my drug use, questioning whether I have let it go too far, and the second time it resulted is me marching to my room and dumping all of my gear down the drain (🐴and ❄️). I’m not mad about it - it was time - and better early than too late right?

Wondering if anyone else has had a similar experience. When I use when I’m out dancing or with friends, it’s all about connection and love, but at home? Questioning my choices and urging me to stop now while I still can.

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u/nopethanks29 — 3 days ago

The ketamine shakes

i havent seen anybody else talk about this so idk if it could just be a “me thing” or not.. does anyone else get mad shakes after a heavy khole? more like tremors i guess, kinda like when ur freezing and get the shakes and ur jaw chatters. i get it only after having a massive khole (~200mg and up) i wonder what causes it. i assume its a neurological effect of ur CNS regaining control but maybe its something else? maybe a hypothermic reaction or something?

if u also get the shakes after a big dose id like to hear ur thoughts about it

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u/Gaib_The_Pulsar — 4 days ago

How to not fall asleep on k

Every time I k hole I fall asleep even on medium dosages like 200mg as soon as I close my eyes after 10 mins I fall asleep I hate that is there a way to solve this problem ?

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u/Material-Ad2327 — 4 days ago

Antidepressant and Psychedelic Drug Interaction Chart

Hello r/ketamine! This Antidepressant and Psychedelic Drug Interaction Chart was previously hosted on the Oregon Health Authority's website, but has apparently been taken down and not reposted. I haven't been able to find it hosted anywhere else reliable, so I'm posting it here as a reference and so that people can link to it.

While it's not entirely clear who created this chart, it does cite sources, so it has some indicia of reliability in my opinion. That said, always be diligent in researching issues related to your health and safety. The absolute best thing to do would be to have an open and honest conversation with the doctor who prescribed your medication about the risks of taking ketamine or any other recreational drug.

u/AluminumOrangutan — 3 days ago

i love rubbing my balls on ketamine

Bro ImDoingFatLines andthen i go to rub my balls because they itchwland then they feelgood bro 👍

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u/qenh — 5 days ago

hallucinations of others

hii, i don’t really use k often anymore (only at events) but when I was more heavily into my use (weekly) I would have a reoccurring phenomenon and I’d like to know if others have had similar experiences. Every single time I used I would hallucinate an extra person in the room with me. It was never a fully formed person more like a shadow being that if I actually looked at wasn’t there. It would happen when I was with other people too. If I was with two other people I thought there was 4 of us in the room. If it was me and another person I thought there was 3 people in the room. I don’t have hallucinations any other time. Has anyone else experienced something like this ?

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u/Advanced_Doughnut524 — 3 days ago

Antidepressant effects vs tolerance

Newby here.

I tried k for the first time yesterday. I think I under dosed at 40mg. just felt sleepy and a nice body relaxation.

I had done dxm before which was way more activating.

The experience was productive as I was able to look into some root fears.

today feeling a hangover type symptoms but also some nice antidepressant effect.

could this be a viable medication at this dose once a fortnight? I’m not worried about getting high so tolerance would not concern me. does tolerance effect the antidepressant effect?

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u/Prior_Comparison_794 — 4 days ago

HELP! How can I cook it NOW

I’ve bought 50ml of k and I don’t have a clue of how to cook it. I did a research here but don’t found any responses. Tried on the microwave but it started to explode in two seconds lol. Don’t have any pyrex or resistant plate sadly

Can I just put it into the pan on low fire with the pan cold? And wait? PRECIATE YALL THANKS!!

Sorry for my weak english. This is my first time
doing k btw

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u/Pablito___ — 5 days ago

Ketamine makes me cry a lot

So my first time doing K was 3 days ago, I wanted to experience this drug because I normally have mental health problems and feel very uneasy in my daily life so I thought why not try… That first day I took 30mg and only felt a buzz, nothing much.

2 days ago I took 80mg and was pretty much high. Not that much tho. After a moment I remember sitting on the floor just sobbing so much about past things that happened in my life, it’s like things burried in my being finally decided to finally come out and it overall felt extremely relieving after I was done. That night, I felt extremely contented for some reason.

I’m not sure why but up to this point, when the ketamine high wears off, I feel really peaceful. Which is quite odd to me. It’s like the after effects are 10x better than the high.

Yesterday I took 150mg in 3 times but didnt K hole. overall my body felt pretty heavy and I just sat there experiencing.I can’t experience anything during the high, but once it wears off it’s like everything just happens and a lot of areas of my life that I’ve struggles with have become so much clearer that I can now work on them outside of ketamine. I’m very grateful for that.

Overall in the last 2 days I’ve cried so much my eyes feel dehydrated, like really a lot of tears. I’m not sure why this is happening, but mostly because seeing things how they really are instead of being in a sort of a "coping state" where I just hide things from myself. It feels like it changed me and made me feel better. If any of you guys have had similar experiences with ketamine please let me know!

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u/SkyAdmirable3150 — 5 days ago

Turning from liquid —> solid

So, I have done K in powder form before but have never gotten my hands on liquid K. I’m sort of familiar with the process of turning the liquid —> powder form. But my main question is this:

How much powder K would I get if I “dried out” a full/sealed vial of the liquid based off this info from the label on vial…

Ketamine HCL 200 mg per 20 mL (10mg/mL)
Each mL contains Ketamine hydrochloride equivalent to 10 mg of Ketamine with a pH range of 3.5-5.5

Is anybody able to help me out and give me a rough estimate of what I might potentially get back in powder form?

Thanks 🙏🏼

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u/brizzybee413 — 4 days ago